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The Center for Vaccine Awareness and Research

Vaccines by disease: Learning more about the live, attenuated influenza vaccine

This vaccine is important because it protects against the influenza virus. Each year, approximately 220,000 people in the United States are hospitalized because of influenza (the flu), and 36,000 die.

Influenza can cause high fevers, pneumonia and seizures in children. Prevention is the key to not contracting the flu, and the most effective preventive method is receiving an annual influenza vaccination.


Who should receive the live, attenuated influenza vaccine?  Live, attenuated influenza vaccine (LAIV) is recommended every year for healthy children who do not have a history of wheesing or asthma and adults aged 2 to 49 years including:

  • Caregivers of children who are between the ages of birth and 59 months
  • Medical professionals, family members and others who come in close contact with people who are at high risk of influenza

People who live in college residences/dormitories or provide essential community services should consider receiving LAIV as well as anyone who wants to lower their risk of contracting influenza.

Live, attenuated influenza vaccine should not be given to:

  • People who are allergic to eggs
  • People who are younger than 2 years or older than 49 years of age
  • People with long-term health conditions including asthma
  • People with weakened immune systems
  • Children or adolescents receiving long-term aspirin treatment
  • Pregnant women
  • People who have had Guillain-Barré Syndrome
  • Health care professionals caring for patients who have had bone marrow transplants

It can take up to two weeks for LAIV to become fully effective. The best time to get this vaccine is in October or November, but even a late vaccination in December or January can be beneficial. Flu season may start as early as October and extend through late May.



When did the live, attenuated influenza vaccine become available?
Since 1945, influenza vaccines have been licensed in the United States. Until 2003, the only influenza vaccine that was available was the inactivated influenza vaccine or the "flu shot." In 2003, the live, attenuated influenza vaccine (LAIV) which is given via intranasal spray, was licensed by the Food and Drug Administration for use in the United States. This vaccine is modified each year with three virus strains that are predicted to be in the United States during the upcoming winter.

How does someone become infected with influenza?
Influenza is most commonly spread from person to person. It also may be spread when a healthy person touches something with the flu virus on it and then touches the nose or mouth.

How effective is the live, attenuated influenza vaccine?
When the virus strains in the vaccine match those viruses circulating in the U.S., LAIV can protect 87 percent of healthy children who have received this vaccine.

Are there any serious side effects of the live, attenuated influenza vaccine?
Serious side effects from the live, attenuated influenza vaccine are quite rare. Mild side effects may include:

  • nasal congestion, runny nose or cough
  • body aches
  • headaches
  • fever
  • abdominal pain, vomiting or diarrhea

Even though this vaccine is made from a live virus, it is weakened and cannot cause influenza.

How do I learn more about this vaccine?
The best person to ask about this or any vaccine is your child’s pediatrician or your primary health care provider. Your provider can answer your questions and give you more information on the live, attenuated influenza vaccine.

Immunization is the best thing you can do for your child and yourself to protect against influenza.
 

 
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